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Is iPS cell the panacea?
Article first published online: 9 FEB 2010
Copyright © 2010 Wiley Periodicals, Inc.
Volume 62, Issue 3, pages 170–175, March 2010
How to Cite
Ou, L., Wang, X. and Zou, F. (2010), Is iPS cell the panacea?. IUBMB Life, 62: 170–175. doi: 10.1002/iub.289
- Issue published online: 12 MAR 2010
- Article first published online: 9 FEB 2010
- Manuscript Accepted: 11 NOV 2009
- Manuscript Received: 20 SEP 2009
- iPS cells;
- natural selection;
In 2006, it was reported that transgenic expression of merely four defined transcription factors (c-Myc, Klf4, Oct4, and Sox2) is sufficient to reprogram somatic cells to a pluripotent state. The resulting induced pluripotent stem (iPS) cells ignited intense interest in the field of life science for their promising applications in basic biology, drug development, and transplantation. However, the underlying problems of iPS cells seem to be ignored. This review shed light on the problems pertaining iPS cells, including the elusive origin, risk of tumorgenesis, and its relationship with natural selection. © 2010 IUBMB IUBMB Life, 62(3): 170–175, 2010