The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis

Authors

  • Andrew Martins,

    1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, N6G 2V4, Canada
    2. Center for Human Immunology, University of Western Ontario, London, Ontario, N6G 2V4, Canada
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  • Jiahuai Han,

    Corresponding author
    1. Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
    • Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA
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    • Tel: (858) 784-8704, Fax: (858) 784-8665

  • Sung O. Kim

    Corresponding author
    1. Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, N6G 2V4, Canada
    2. Center for Human Immunology, University of Western Ontario, London, Ontario, N6G 2V4, Canada
    • Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, N6G 2V4, Canada
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    • Tel: (519) 850-2961. Fax: (519) 661-2046


Abstract

The three colony-stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte colony-stimulating factor (G-CSF), have been regarded as immunostimulators because of their role in granulocyte and myeloid hematopoiesis and immune function. However, unlike GM-CSF and M-CSF, G-CSF possesses immunosuppressive effects on other immune cells including monocytes/macrophages, dendritic cells, and T lymphocytes when exogenously administered. Given the immunomodulatory effects of exogenous G-CSF, endogenous G-CSF may also play an important role in maintaining local immune homeostasis in tissue in which it is highly and constitutively produced. This review highlights the potential role of G-CSF in immunomodulation and intestinal immune homeostasis. © 2010 IUBMB IUBMB Life, 62(8): 611–617, 2010.

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