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The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis
Article first published online: 28 JUL 2010
Copyright © 2010 Wiley Periodicals, Inc.
Volume 62, Issue 8, pages 611–617, August 2010
How to Cite
Martins, A., Han, J. and Kim, S. O. (2010), The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis. IUBMB Life, 62: 611–617. doi: 10.1002/iub.361
- Issue published online: 28 JUL 2010
- Article first published online: 28 JUL 2010
- Manuscript Accepted: 15 JUN 2010
- Manuscript Received: 14 JUN 2010
- granulocyte colony-stimulating factor;
- inflammatory bowel disease
The three colony-stimulating factors, granulocyte/macrophage colony-stimulating factor (GM-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte colony-stimulating factor (G-CSF), have been regarded as immunostimulators because of their role in granulocyte and myeloid hematopoiesis and immune function. However, unlike GM-CSF and M-CSF, G-CSF possesses immunosuppressive effects on other immune cells including monocytes/macrophages, dendritic cells, and T lymphocytes when exogenously administered. Given the immunomodulatory effects of exogenous G-CSF, endogenous G-CSF may also play an important role in maintaining local immune homeostasis in tissue in which it is highly and constitutively produced. This review highlights the potential role of G-CSF in immunomodulation and intestinal immune homeostasis. © 2010 IUBMB IUBMB Life, 62(8): 611–617, 2010.