• 1
    Magnuson, M. A. andMatschinsky, F. M. ( 2004) Glucokinase as a glucose sensor: past, present and future. In: Glucokinase and Glycemic Disease: From Basics to Novel Therapeutics. Front Diabetes, Vol. 16 ( Matschinsky, F. M.,Magnuson, M. A., eds.). pp. 117, Basel, Karger.
  • 2
    Kamata, K.,Mitsuya, M.,Nishimura, T.,Eiki, J., andNagata, Y. ( 2004) Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure 12, 429438.
  • 3
    Iynedjian, P. B. ( 1993) Mammalian glucokinase and its gene. Biochem. J. 293, 113
  • 4
    Iynedjian, P. B. ( 2009) Molecular physiology of mammalian glucokinase. Cell Mol. Life Sci. 66, 2742.
  • 5
    Iynedjian, P. B.,Gjinovci, A., andRenold, A. E. ( 1988) Stimulation byinsulin of glucokinase gene transcription in liver of diabetic rats. J. Biol. Chem. 263, 740744.
  • 6
    Wu, C.,Okar, D. A.,Stoeckman, A. K.,Peng, L. J.,Herrera, A. H.,Herrera, J. E.,Towle, H. C., andLange, A. J. ( 2004) A potential role for fructose-2,6-biphosphatase in the stimulation of hepatic glucokinase gene expression. Endocrinology 145, 650658.
  • 7
    Matsumoto, M.,Pocai, A.,Rossetti, L.,Depinho, R. A., andAccili, D. ( 2007) Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo1 in liver. Cell Metab. 6, 208216.
  • 8
    Roth, U.,Curth, K.,Unterman, T. G., andKietzmann, T. ( 2004) The transcriptional factors HIF-1 and HNF-4 and the coactivator p300 are involved in insulin-regulated glucokinase gene expression via the phosphatidylinositol 3-kinase/protein kinase B pathway. J. Biol. Chem. 279, 26232631.
  • 9
    Kietzmann, T.,Roth, U.,Freimann, S., andJungermann, K. ( 1997) Arterial oxygen partial pressures reduce the insulin-dependent induction of the perivenously located glucokinase in rat hepatocytes cultures: mimicry of arterial oxygen pressures by H2O2. Biochem. J. 321, 1720.
  • 10
    Foretz, M.,Guichard, C.,Ferre, P., andFoufelle, F. ( 1999) Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc. Natl. Acad. Sci. USA 96, 1273712742.
  • 11
    Kim, T. H.,Kim, H.,Park, J. M.,Im, S. S.,Bae, J. S.,Kim, M. Y.,Yoon, H. G.,Cha, J. Y.,Kim, K. S., andAhn, Y. H. ( 2009) Interrelationship between liver X receptor α, sterol regulatory element-binding protein-1C, peroxisome proliferator-activated receptor γ, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver. J. Biol. Chem. 284, 1507115083.
  • 12
    Stoeckman, A. K. andTowle, H. C. ( 2002) The role of SREBP-1c in nutritional regulation of lipogenic enzyme gene expression. J. Biol. Chem. 277, 2702927035.
  • 13
    Liang, G.,Yang, J.,Horton, J. D.,Hammer, R. E.,Goldstein, J. L., andBrown, M. S. ( 2002) Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J. Biol. Chem. 277, 95299528.
  • 14
    Hansmannel, F.,Mordier, S., andIynedjian, P. B. ( 2006) Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the role of sterol-regulatory-element-binding protein-1c and liver X receptor. Biochem. J. 399, 275283.
  • 15
    Narkewicz, M. R.,Iynedjian, P. B.,Ferrer, P., andGirard, J. ( 1990) Insulin and tri-iodothyronine induce glucokinase mRNA in primary cultures of neonatal rat hepatocytes. Biochem. J. 271, 585589.
  • 16
    Wang, Z.,Iwasaki, Y.,Zhao, L. F.,Nishiyama, M.,Taguchi, T.,Tsugita, M.,Kambayashi, M.,Hashimoto, K., andTerada, Y. ( 2009) Hormonal regulation of glycolitic enzyme gene and pyruvate dehydrogenase kinase/phosphatase gene transcription. Endocr. J. 56, 10191030.
  • 17
    Zhu, L. L.,Liu, Y.,Shao, D.,Liang, J. C.,Liu, X. J.,Chen, Y.,Gupta, N.,Fang, F. D., andChang, Y. S. ( 2010) PGC-1alpha coactivates estrogen-related receptor-alpha to induce the expression of glucokinase. Am. J. Physiol. Endocrinol. Metab. 298, E1210E1218.
  • 18
    Jiang, M. H.,Fei, J.,Lan, M. S.,Lu, Z. P.,Liu, M.,Fan, W. W.,Gao, X., andLu, D. R. ( 2008) Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential. Diabetologia 51, 15251533.
  • 19
    Van Schaftingen, E.,Detheux, M., andVeiga Da Cunha, M. ( 1994) Short-term control of glucokinase activity: role of a regulatory protein. FASEB J. 8, 414419.
  • 20
    Futamura, M.,Hosaka, H.,Kadotani, A.,Shimazaki, H.,Sasaki, K.,Ohyama, S.,Nishimura, T.,Eiki, J., andNagata, Y. ( 2006) An allosteric activator of glucokinase impairs the interaction of glucokinase regulatory protein and regulates glucose metabolism. J. Biol. Chem. 281, 3766837674.
  • 21
    de la Iglesia, N.,Veiga da-Cunha, M.,Van schaftingen, E.,Guinovart, J. J.,Ferrer, J. C. ( 1999) Glucokinase regulatory protein is essential for the proper subcellular localization of liver glucokinase. FEBS Lett. 456, 332338.
  • 22
    Veiga-da-Cunha, M.,Courtois, S.,Michel, A.,Gosselain, E., andVan Schaftingen, E. ( 1996) Amino acid conservation in animal glucokinase: identification of residues implicated in the interaction with the regulatory protein. J. Biol. Chem. 271, 62926297.
  • 23
    Baltrusch, S.,Francini, F.,Lenzen, S., andTiedge, M. ( 2005) Interaction of glucokinase with the liver regulatory protein is conferred by leucine-asparagine motifs of the enzyme. Diabetes 54, 28292837.
  • 24
    Farrelly, D.,Brown, K. S.,Tieman, A.,Ren, J.,Lira, S. A.,Hagan, D.,Gregg, R.,Mookhtiar, K. A., andHariharan, N. ( 1999) Mice mutant for glucokinase regulatory protein exhibit decreased liver glucokinase: a sequestration mechanism in metabolic regulation. Proc. Natl. Acad. Sci. USA 96, 1451114516.
  • 25
    Shiota, C.,Coffey, J.,Grimsby, J.,Grippo, J. F., andMagnuson, M. A. ( 1999) Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase. J. Biol. Chem. 274, 3712537130.
  • 26
    Mukhtar, M.,Stubbs, M., andAgius, L. ( 1999) Evidence for glucose and sorbitol-induced nuclear export of glucokinase regulatory protein in hepatocytes. FEBS Lett. 462, 453458.
  • 27
    Baltrusch, S.,Lenzen, S.,Okar, D. A.,Lange, A. J., andTiedge, M. ( 2001) Characterization of glucokinase-binding protein epitopes by aphage-displayed peptide library. Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel interaction partner. J. Biol. Chem. 276, 4391543923.
  • 28
    Massa, L.,Baltrusch, S.,Okar, D. A.,Lange, A. J.,Lenzen, S., andTiedge, M. ( 2004) Interaction of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK-2/FBPase-2) with glucokinase activates glucose phosphorylation and glucose metabolism in insulin-producing cells. Diabetes 53, 10201029.
  • 29
    Smith, W. E.,Langer, S.,Wu, Ch.,Baltrusch, S., andOkar, D. A. ( 2007) Molecular coordination of hepatic glucose metabolism by the 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase:glucokinase complex. Mol. Endocrinol. 21, 14781487.
  • 30
    Payne, V. A.,Arden, C.,Wu, C.,Lange, A. J., andAgius, L. ( 2005) Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes. Diabetes 54, 19491956.
  • 31
    Agius, L. andPeak, M. ( 1993) Intracellular binding of glucokinase in hepatocytes and translocation by glucose, fructose and insulin. Biochem. J. 296, 785796.
  • 32
    Payne, V. A.,Arden, C.,Lange, A. J., andAgius, L. ( 2007) Contribution of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293, R618R625.
  • 33
    Francini, F.,Castro, C.,Gagliardino, J. J., andMassa, M. L. ( 2009) Regulation of liver glucokinase activity in rats with fructose-induced insulin resistance and impaired glucose and lipid metabolism. Can. J. Physiol. Pharmacol. 87, 702710.
  • 34
    Wu, C.,Okar, D. A.,Newgard, C. B., andLange, A. J. ( 2001) Overexpression of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in mouse liver lowers blood glucose by suppressing hepatic glucose production. J. Clin. Invest. 107, 9198.
  • 35
    Watanabe, F. andFuruya E. ( 2010) Quantitative image analysis reveals that phosphorylation of liver-type isozyme of fructose-6-phosphate 2- kinase/fructose-2,6-biphosphatase does not affect nuclear translocation of glucokinase in rat primary hepatocytes. J. Biochem. 148(6), 713719.
  • 36
    Danial, N. N.,Gramm, C. F.,Scorrano, L.,Zhang, Ch.-Y.,Krauss, S.,Ranger, A. M.,Datta, S. R.,Greenberg, M. E.,Licklider, L. J.,Lowell, B. B.,Gygi, S. P., andKorsmeyer, S. J. ( 2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424, 952956.
  • 37
    Arden, C.,Baltrusch, S., andAgius, L. ( 2006) Glucokinase regulatory protein is associated with mitochondria in hepatocytes. FEBS Letters 580, 20652070.
  • 38
    Bustamante, E.,Pediaditakis, P.,He, L., andLemasters, J. J. ( 2005) Isolated mouse liver mitochondria are devoid of glucokinase. Biochem. Biophys. Res. Commun. 334, 907910.
  • 39
    Postic, C.,Shiota, M.,Niswender, K. D.,Jetton, T. L.,Chen, Y.,Moates, J. M.,Shelton, K. D.,Lindner, J.,Cherrington, A. D., andMagnuson, M. A. ( 1999) Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic B-cell specific gene knock-outs using Cre recombines. J. Biol. Chem. 274, 305315.
  • 40
    Byrne, M. M.,Sturis, J.,Clement, K.,Vionnet, N.,Pueyo, M. E.,Stoffel, M.,Takeda, J.,Passa, P.,Cohen, D.,Bell, G. L.,Velho, G.,Froguel, P., andPolonsky, K. S. ( 1994) Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations. J. Clin. Invest. 93, 11201130.
  • 41
    Caro, J. F.,Triester, S.,Patel, V. K.,Tapscott, E. B.,Frazier, N. F., andDohm, G. L. ( 1995) Liver glucokinase: decreased activity in patients with type II diabetes. Horm. Metab. Res. 27, 1922.
  • 42
    Grimsby, J.,Sarabu, R.,Corbett, W. L.,Haynes, N. E.,Bizzarro, F. T.,Coffey, J. W.,Guertin, K. R.Hilliard, D. W.,Kester, R. F.,Mahaney, P. E.,Marcus, L.,Qi, L.,Spence, C. L.,Tengi, J.,Magnuson, M. A.,Chu, C. A.,Dvorozniak, M. T.,Matschinsky, F. M., andGrippo, J. F. ( 2003) Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301, 370373.
  • 43
    Bebernitz, G. R.,Beaulieu, V.,Dale, B. A.,Deacon, R.,Duttaroy, A.,Gao, J.,Grondine, M. S.,Gupta, R. C.,Kakmak, M.,Kavana, M.,Kirman, L. C.,Liang, J.,Maniara, W. M.,Munshi, S.,Nadkarni, S. S.,Schuster, H. F.,Stams, T.,Denny, I. S.,Taslimi, P. M.,Vash, B., andCaplan, S. L. ( 2009) Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. J. Med. Chem. 52, 61426152.
  • 44
    Belfiore, F.,Romeo, F.,Iannello, S., andSalamone, C. ( 1989) The glucose-6-phosphatase/glucokinase ratio in the liver of obese-diabetic subjects. Biochem. Med. Metab. Biol. 41, 7780.
  • 45
    Huuponen, R.,Karvonen, I., andSotaniemi, E. ( 1989) Activity of hepatic glucose phosphorylating and NADPH generating enzymes in Zucker rat. Diabetes Res. 10, 143146.
  • 46
    Ferre, T.,Riu, E.,Franckhauser, S.,Agudo, J., andBosch, F. ( 2003) Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance. Diabetologia 46, 16621668.
  • 47
    Kim, J. Y.,Song, E. H.,Lee, H. J.,Oh, Y. K.,Park, Y. S.,Park, J.-W.,Kim, B. J.,Kim, D. J.,Lee, I.,Song, J., andKim, W.-H. ( 2010) Chronic ethanol consumption induced pancreatic B-cell dysfunction and apoptosis through GCK nitration and its downregulation. J. Biol. Chem. 285(48), 3725137262.