Microarray-based DNA profiling to study genomic aberrations


  • Nic Waddell

    Corresponding author
    1. Queensland Institute of Medical Research, Queensland, Australia
    • Queensland Institute of Medical Research, Royal Brisbane Hospital Post Office, Herston, QLD 4029, Australia
    Search for more papers by this author
    • Tel: 617 3362 0336. Fax: 617 3362 0105

  • From time to time we republish review articles from the Australian Biochemist, the magazine of the Australian Society for Biochemistry and Molecular Biology, Inc. This exposes these excellent reviews to a much wider and different readership. Here we republish a review on microarray-based DNA profiling that originally appeared in the Australian Biochemist, Volume 38, December 2007. We are most grateful for the permission of Nic Waddell and of Rebecca Lew, the Editor of the Australian Biochemist, to republish this review.


High throughput microarrays were initially developed to analyse the expression of many RNA transcripts in parallel. The technology has since been adapted to a variety of applications, one of which is the analysis of the genome to study DNA dosage and sequence content. Advances in microarray fabrication and completion of large-scale genome sequencing projects have enabled the rapid development of affordable array-based methods for high-resolution genome-wide assessment of DNA alterations. This review will describe the evolution of microarray assays to study genomic aberrations and will highlight how they have enabled researchers to gain insight into the biology of human diseases and how they will benefit research in the future. © 2008 IUBMB IUBMB Life, 60(7): 437–440, 2008