Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene
Article first published online: 24 APR 2012
© 2012 European Federation of International Association for the Study of Pain Chapters
European Journal of Pain
Volume 17, Issue 1, pages 16–27, January 2013
How to Cite
Martínez-Jauand, M., Sitges, C., Rodríguez, V., Picornell, A., Ramon, M., Buskila, D. and Montoya, P. (2013), Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene. European Journal of Pain, 17: 16–27. doi: 10.1002/j.1532-2149.2012.00153.x
Research was supported by grants from the Regional Government of the Balearic Islands (Acciones Especiales #AAEE0027/08), Spanish Ministry of Education (grant #AP2008-03742 awarded to M.M.J.) and Spanish Ministry of Science and Innovation and European regional development funds (grant #PSI2010-19372 awarded to P.M.), and La Marato TV3 Foundation.
Conflicts of interest
- Issue published online: 11 DEC 2012
- Article first published online: 24 APR 2012
- Manuscript Accepted: 26 MAR 2012
- Regional Government of the Balearic Islands. Grant Number: #AAEE0027/08
- Spanish Ministry of Education. Grant Number: #AP2008-03742
- Spanish Ministry of Science and Innovation and European regional development funds. Grant Number: #PSI2010-19372
- La Marato TV3
Recent evidence suggests that genetic factors might contribute to individual differences in pain sensitivity, risk for developing clinical pain conditions and efficacy of pain treatments. The purpose of the present study was to investigate the relationship of three common haplotypes of COMT gene affecting the metabolism of catecholamines on pain sensitivity in patients with fibromyalgia (FM).
One hundred and thirteen FM patients and 65 age-matched healthy volunteers participated in the study. We genotyped four single-nucleotide polymorphisms (SNPs) (rs6269, rs4633, rs4818 and rs4680 or Val158Met) and identified haplotypes previously designated as low (LPS), average (APS) and high pain sensitivity (HPS). Thermal, pressure and touch thresholds were also examined using a quantitative sensory testing protocol.
The frequency of genetic variations associated with low COMT enzyme activity was significantly higher in FM patients than in healthy volunteers. FM patients were more sensitive to experimental pain than healthy volunteers and, in particular, FM individuals with the met/met genotype (Val158Met SNP) or the HPS-APS haplotypes showing higher sensitivity to thermal and pressure pain stimuli than patients carrying the LPS haplotype or val alleles (Val158Met SNP). No differences due to genotype or haplotypes were found on non-painful touch thresholds.
According with previous research, our findings revealed that haplotypes of the COMT gene and genotypes of the Val158Met polymorphism play a key role on pain sensitivity in FM patients.