St. John's wort relieves pain in an animal model of migraine
Version of Record online: 14 NOV 2012
© 2012 European Federation of International Association for the Study of Pain Chapters
European Journal of Pain
Volume 17, Issue 3, pages 369–381, March 2013
How to Cite
Galeotti, N. and Ghelardini, C. (2013), St. John's wort relieves pain in an animal model of migraine. European Journal of Pain, 17: 369–381. doi: 10.1002/j.1532-2149.2012.00196.x
Conflict of interest
- Issue online: 6 FEB 2013
- Version of Record online: 14 NOV 2012
- Manuscript Accepted: 4 JUN 2012
Figure S1. Time course of the expression and phosphorylation of PKCγ and PKCε by NO donors administration. GTN (A) and SNP (B) increased pPKCγ and pPKCε 1, 2 and 4 h after administration, whereas at 6 h the protein levels returned comparable to control values. Administration of calphostin C (C; 0.2 μg per mouse i.c.v.) counteracted the upregulation of pPKCγ and pPKCε. Increased levels of total PKCγ (C) and PKCε (D) was also detected 2 and 4 h after NO donors' administration.
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