Clinical evidence of parietal cortex dysfunction and correlation with extent of allodynia in CRPS type 1
Article first published online: 7 NOV 2012
© 2012 European Federation of International Association for the Study of Pain Chapters
European Journal of Pain
Volume 17, Issue 4, pages 527–538, April 2013
How to Cite
Cohen, H., McCabe, C., Harris, N., Hall, J., Lewis, J. and Blake, D.R. (2013), Clinical evidence of parietal cortex dysfunction and correlation with extent of allodynia in CRPS type 1. European Journal of Pain, 17: 527–538. doi: 10.1002/j.1532-2149.2012.00213.x
Dr Cohen was supported by Arthritis Research UK (Grant No. 17573).
Conflicts of interest
No conflict of Interest has been declared by the authors.
- Issue published online: 14 MAR 2013
- Article first published online: 7 NOV 2012
- Manuscript Accepted: 23 JUL 2012
- Arthritis Research UK. Grant Number: 17573
Unusual symptoms such as digit misidentification and neglect-like phenomena have been reported in complex regional pain syndrome (CRPS), which we hypothesized could be explained by parietal lobe dysfunction.
Twenty-two patients with chronic CRPS attending an in-patient rehabilitation programme underwent standard neurological examination followed by clinical assessment of parietal lobe function and detailed sensory testing.
Fifteen (68%) patients had evidence of parietal lobe dysfunction. Six (27%) subjects failed six or more test categories and demonstrated new clinical signs consistent with their parietal testing impairments, which were impacting significantly on activities of daily living. A higher incidence was noted in subjects with >1 limb involvement, CRPS affecting the dominant side and in left-handed subjects.
Eighteen patients (82%) had mechanical allodynia covering 3–57.5% of the body surface area. Allochiria (unilateral tactile stimulation perceived only in the analogous location on the opposite limb), sensory extinction (concurrent bilateral tactile stimulation perceived only in one limb), referred sensations (unilateral tactile stimulation perceived concurrently in another discrete body area) and dysynchiria (unilateral non-noxious tactile stimulation perceived bilaterally as noxious) were present in some patients. Greater extent of body surface allodynia was correlated with worse parietal function (Spearman's rho = −0.674, p = 0.001).
In patients with chronic CRPS, detailed clinical examination may reveal parietal dysfunction, with severity relating to the extent of allodynia.