Leptin and the Development of Obesity and Diabetes in Psammomys obesus
Version of Record online: 6 SEP 2012
1997 North American Association for the Study of Obesity (NAASO)
Volume 5, Issue 5, pages 455–458, September 1997
How to Cite
Collier, G. R., Walder, K., Lewandowski, P., Sanigorski, A. and Zimmetf, P. (1997), Leptin and the Development of Obesity and Diabetes in Psammomys obesus. Obesity Research, 5: 455–458. doi: 10.1002/j.1550-8528.1997.tb00670.x
- Issue online: 6 SEP 2012
- Version of Record online: 6 SEP 2012
- Accepted for publication April 23, 1997
- Cited By
- Psammomys obesus
COLLIER, GREG R, KEN WALDER, PAUL LEWAN DOWSJCI, ANDREW SANIGORSKI, PAUL ZIMMET. Leptin and the development of obesity and diabetes in Psammomys obesus.
The recently discovered ob gene and its circulating product, leptin, may be critical factors in the control of energy balance. Recent studies in ob/ob mice, which lack circulating leptin, have shown dramatic reductions in food intake and bodyweight after leptin treatment. In addition, studies in both humans with obesity and animal models of obesity have demonstrated hyperleptinemia. Here, we report a longitudinal study examining changes in circulating leptin during the development of obesity and diabetes in Psammomys obesus. Over the 8 weeks of the study, lean animals increased their bodyweight by 154% and leptin levels remained essentially unchanged. In contrast, animals that developed obesity (223 % increase in bodyweight), hyperglycemia, and hyperinsulinemia also developed hyperleptinemia between 4 weeks and 8 weeks of age. These results demonstrate that the development of hyperleptinemia is associated with the development of obesity and subsequent metabolic abnormalities.