Atorvastatin Does Not Alter the Anticoagulant Activity of Warfarin



Twelve patients chronically maintained on warfarin were administered 80 mg atorvastatin for 2 weeks. Mean prothrombin times decreased slightly, but only for the first few days of the two-week treatment period. Thus atorvastatin had no consistent effect on the anticoagulant activity of warfarin and adjustments in warfarin dosing should not be necessary.