ORIGINAL RESEARCH ARTICLE
Influence of Pill Burden and Drug Cost on Renal Function After Transplantation
Version of Record online: 30 MAR 2012
© 2012 Pharmacotherapy Publications, Inc
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
Volume 32, Issue 5, pages 427–432, May 2012
How to Cite
Hardinger, K. L., Hutcherson, T., Preston, D. and Murillo, D. (2012), Influence of Pill Burden and Drug Cost on Renal Function After Transplantation. Pharmacotherapy, 32: 427–432. doi: 10.1002/j.1875-9114.2012.01032.x
- Issue online: 2 MAY 2012
- Version of Record online: 30 MAR 2012
- renal function
To determine the influence of pill burden and drug cost on outcomes after renal transplantation.
Retrospective medical record review.
Kidney and pancreas transplantation center.
Sixty-eight adults who underwent kidney or kidney-pancreas transplantation during 2007.
Measurements and Main Results
The median pretransplantation pill burden was 15 pills/day, which increased to 25 pills/day at 1 month after transplantation and returned to 16 pills/day by 1 year after transplantation. Pretransplantation pill burden was lower than the burden at 1, 3, 6, 12, and 24 months after transplantation (p<0.05). The mean pretransplantation drug cost of $1918/month was lower than the cost at 1 month after transplantation ($2564/mo, p=0.04) but was similar thereafter. Higher pretransplantation pill burden was associated with increased serum creatinine concentration at 6 months after transplantation (r=0.288, p=0.017). Higher pill burdens at 1 month (r=0.364, p=0.002), 3 months (r=0.332, p=0.006), and 6 months (r=0.374, p=0.002) were associated with increased 3-month serum creatinine concentration. Higher drug costs were associated with increased serum creatinine concentrations throughout the study.
Higher pretransplantation pill burden and higher drug cost may be associated with poor renal function after transplantation. Further study addressing factors associated with nonadherence is needed.