Persons with the chronic illness of multiple sclerosis now live longer than ever. Rehabilitation nurses encounter many of these patients in their work, helping them adapt to the constraints and limitations imposed by the disease. Although a diagnosis of multiple sclerosis is characterized by uncertainty, much can be done to help patients and their families deal with the complications of the disease process, which may affect many areas of daily living. To provide comprehensive care, an understanding of the pathophysiology and medical management of multiple sclerosis and a creative use of nursing expertise is necessary. Much of the care rendered to these patients and their families is provided by nurses. This care can be organized through the framework of nursing diagnosis, which identifies functional deficits amenable to nursing care.