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Sexuality concerns of the post-stroke patient often are overlooked in the clinical setting during rehabilitation and post-discharge care. Research has indicated that patients welcome frank and open discussion of the topic, although it seldom occurs. Research findings also indicate that changes in sexuality after a stroke often are due to changes in role function because of the increased dependency of the afflicted partner. This article discusses the research related to sexuality in the post-stroke patient, as well as indicators of sexual dysfunction in this population. Research findings are related to nursing care. Specific patient examples are given, along with suggestions for incorporating assessment of sexuality concerns into nursing care of the post-stroke patient.