This study examined the relationship between caregiver burden and self-care deficit in former rehabilitation patients. We hypothesized that as self-care deficit increases, so does the level of caregiver burden. We employed Spearman correlational analysis and stepwise multiple regression analyses; the mean caregiver burden score was 25.9 (SD = 17.1), indicating mild to moderate burden. Caregiver burden was significantly correlated with social cognition deficit (r = 0.438, p = .001), communication deficit (r = 0.430, p = .001), and self-care deficit (r = .426, p = .002). Significant predictors of burden were social cognition deficit (β = .408, p = .0018), self-care deficit (β = .322, p = .0100), and caregiver age (β = .369, p = .0312).