There are many adults with disabilities currently in the United States, yet little is known about how gender differences affect stroke risk factors in this population. This article presents a descriptive study that was designed to determine whether males and females living with disabilities differ in self-reported rates of stroke risk factors. Data were collected at conferences and meetings targeted for people living with disabilities. There were 146 participants; 54% were female; and the mean age was 58 years. The primary instrument was the Stroke Risk Screening tool. Stroke risk factors that differed significantly by gender include the incidence of hypertension (48% of men versus 32% of women), current smoking (30% men versus 4% women), history of heart disease (13% men versus 1% women), daily consumption of alcohol (10% men versus 1% women), and use of illicit drugs (10% men versus 0% women). Rehabilitation nurses should focus on earlier assessment of stroke risk factors and appropriate interventions, especially with men living with disabilities.