In 2005, the board of directors of the Association of Rehabilitation Nurses (ARN) directed the Rehabilitation Nursing Foundation (RNF) to evaluate and revise the Rehabilitation Nursing Research Agenda. Following a review of the processes used by other nursing organizations to evaluate their research agendas, RNF first evaluated the effectiveness of the agenda, and then RNF embarked on a process to update and revise the agenda. The process included generating new and revised statements of research priorities based on the evaluation process, followed by a survey of members of ARN to rate the relevance of each statement to the profession. The results are a new Rehabilitation Nursing Research Agenda consisting of 19 statements of research priorities grouped into four categories. This new agenda has the potential to drive rehabilitation nursing research for the next 10 years.