Murat Ersoz, MD, is an associate professor of physical medicine and rehabilitation and vice clinical chief at Ankara Physical Medicine and Rehabilitation Training and Research Hospital of Ministry of Health in Ankara, Turkey.
Efficacy of Combined Oral-Intravesical Oxybutynin Hydrochloride Treatment for Patients with Overactive Detrusors and Indwelling Urethral Catheters
Article first published online: 27 MAR 2012
2010 Association of Rehabilitation Nurses
Volume 35, Issue 2, pages 80–86, March-April 2010
How to Cite
Ersoz, M., Yildiz, N., Akyuz, M. and Koseoglu, F. (2010), Efficacy of Combined Oral-Intravesical Oxybutynin Hydrochloride Treatment for Patients with Overactive Detrusors and Indwelling Urethral Catheters. Rehabilitation Nursing, 35: 80–86. doi: 10.1002/j.2048-7940.2010.tb00036.x
- Issue published online: 27 MAR 2012
- Article first published online: 27 MAR 2012
- detrusor overactivity;
- indwelling urethral;
- intravesical oxybutinin;
- spinal cord injury;
The purpose of this article is to investigate the efficacy of intravesical oxybutynin hydrochloride (OH) to treat patients with overactive detrusors who are unresponsive to oral anticholinergic therapy alone. Twenty-five patients who were treated with oral OH for overactive detrusor (but who did not respond to treatment and were using indwelling urethral catheters) were given intravesical OH without changing oral treatment. Pre- and posttreatment bladder capacities were compared in urodynamic studies. The study showed that positive clinical results can be achieved with combined oral and intravesical OH treatments in patients with overactive detrusors who had indwelling urethral catheters because of severely reduced bladder capacity. However, a significant number of patients discontinued this treatment because of infection and difficulty in performing the procedure. Clinicians and rehabilitation nurses should provide education and support to eliminate these problems. In addition, the development of single-use standard sterile OH preparations for intravesical applications may increase the efficacy of the method.