To expand work-family conflict (WFC) research to specific occupations, this study investigated how work and family generic and occupation-specific stressors and support variables related to family interfering with work (F [RIGHTWARDS ARROW] W) and work interfering with family (W [RIGHTWARDS ARROW] F) among 230 Israeli high school teachers. Further expanding WFC research, the authors assessed WFC effects on burnout and vigor. Results indicated that W [RIGHTWARDS ARROW] F conflict was related to generic variables and more so to distinctive teaching characteristics (e.g., investment in student behavior and parent-teacher relations). Both W [RIGHTWARDS ARROW] F and F [RIGHTWARDS ARROW] W predicted burnout, whereas only F [RIGHTWARDS ARROW] W predicted vigor. Implications for WFC research and occupational health programs are discussed.