Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts
Article first published online: 3 JAN 2006
Copyright © 2006 John Wiley & Sons, Ltd.
Journal of Applied Toxicology
Volume 26, Issue 3, pages 229–238, May/June 2006
How to Cite
Abdel-Wahhab, M. A., Ahmed, H. H. and Hagazi, M. M. (2006), Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts. J. Appl. Toxicol., 26: 229–238. doi: 10.1002/jat.1127
- Issue published online: 5 MAY 2006
- Article first published online: 3 JAN 2006
- Manuscript Revised: 29 SEP 2005
- Manuscript Accepted: 29 SEP 2005
- Manuscript Received: 16 FEB 2005
- tumor marker;
- Laurencia obtusa;
- Caulerpa prolifera
Chemoprevention by extracts of Laurencia obtusa (E1) and Caulerpa prolifera (E2) collected from the Egyptian coast of the Red Sea against aflatoxin B1 (AFB1)-initiated hepatotoxicity in female Sprague-Dawley rats has been studied. Animals were fed aflatoxin-contaminated diet (3 mg kg−1 diet) for 6 days then treated orally with pure aflatoxin B1 (AFB1) (200 µg kg−1 b.w.) for 4 days either in combination with or before E1 or E2 administration (50 mg kg−1 b.w.). AFB1 resulted in a signicant increase in serum alpha fetoprotein, carcinoembryonic antigen, tumor necrosis factor alpha, nitric oxide, interleukin-1α, procollagen III and lipid peroxidation level in the liver. It caused a signicant decrease in food intake, body weight, serum leptin, the activities of glutathione peroxidase, superoxide dismutase and DNA and RNA concentrations in the liver. Cotreatment with AFB1 and E1 or E2 resulted in an obvious improvement in all tested parameters. Noteworthy, E2 was more effective than E1 in the protection against AFB1-induced hepatotoxicity. Copyright © 2006 John Wiley & Sons, Ltd.