This article is a U.S. Government work and is in the public domain in the U.S.A.
Comparative effects of prolonged administration of cyanide, thiocyanate and chokecherry (Prunus virginiana) to goats†
Article first published online: 13 JUL 2007
Copyright © 2007 John Wiley & Sons, Ltd.
Journal of Applied Toxicology
Volume 28, Issue 3, pages 356–363, April 2008
How to Cite
Soto-Blanco, B., Stegelmeier, B. L., Pfister, J. A., Gardner, D. R. and Panter, K. E. (2008), Comparative effects of prolonged administration of cyanide, thiocyanate and chokecherry (Prunus virginiana) to goats. J. Appl. Toxicol., 28: 356–363. doi: 10.1002/jat.1286
- Issue published online: 20 MAR 2008
- Article first published online: 13 JUL 2007
- Manuscript Accepted: 29 MAY 2007
- Manuscript Revised: 27 APR 2007
- Manuscript Received: 5 JAN 2007
- cyanogenic plants;
- poisonous plants;
- Prunus virginiana;
The aim of the present study was to determine and compare the clinical, hematological, biochemical and histopathological changes induced by cyanide, thiocyanate and chokecherry (Prunus virginiana) in goats. Sixteen Boer-Spanish cross-bred female goats were divided into four treatment groups: (1) control, (2) potassium cyanide (KCN) at 3.8 mg kg−1 day−1, (3) potassium thiocyanate (KSCN) at 4.5 mg kg−1 day−1 and (4) ground frozen chokecherry leaves and flowers at a target dose of 2.5 mg HCN kg−1 day−1, all for 4 weeks. Clinical signs were observed in two goats treated with chokecherry. Only sporadic changes were found in the hematological and blood chemical panel. Goats treated with chokecherry and thiocyanate had an increased number of vacuoles in the colloid of thyroid glands. Spongiosis and spheroids were found in the mesencephalon from goats treated with KCN and chokecherry. These findings suggest the thyroid lesions can be attributed to thiocyanate, whereas the effects on the nervous system were most likely caused by cyanide. Published in 2007 by John Wiley & Sons, Ltd.