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Research Article

Cytotoxicity and biological effects of functional nanomaterials delivered to various cell lines

  1. Meena Mahmood1,
  2. Daniel A. Casciano1,*,
  3. Teodora Mocan2,
  4. Cornel Iancu2,
  5. Yang Xu1,
  6. Lucian Mocan2,
  7. Dana Todea Iancu2,
  8. Enkeleda Dervishi1,
  9. Zhongrui Li1,
  10. Mustafa Abdalmuhsen1,
  11. Alexandru R. Biris3,
  12. Nawab Ali1,
  13. Paul Howard4,
  14. Alexandru S. Biris2,*

Article first published online: 16 SEP 2009

DOI: 10.1002/jat.1475

Issue

Journal of Applied Toxicology

Journal of Applied Toxicology

Volume 30, Issue 1, pages 74–83, January 2010

Additional Information

How to Cite

Mahmood, M., Casciano, D. A., Mocan, T., Iancu, C., Xu, Y., Mocan, L., Iancu, D. T., Dervishi, E., Li, Z., Abdalmuhsen, M., Biris, A. R., Ali, N., Howard, P. and Biris, A. S. (2010), Cytotoxicity and biological effects of functional nanomaterials delivered to various cell lines. J. Appl. Toxicol., 30: 74–83. doi: 10.1002/jat.1475

Author Information

  1. 1

    University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Graduate Institute of Technology, Little Rock, AR 72204, USA

  2. 2

    University of Medicine and Pharmacy ‘Iuliu Hatieganu’, Surgery Clinic III, Cluj-Napoca, 3400, Romania

  3. 3

    National Institute for Research and Development of Isotopic and Molecular Technologies, PO Box 700, R-400293 Cluj-Napoca, Romania

  4. 4

    National Center for Toxicology Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA

*University of Arkansas at Little Rock, Applied Science Department, Nanotechnology Center, Little Rock, AR 72204, USA

Publication History

  1. Issue published online: 16 DEC 2009
  2. Article first published online: 16 SEP 2009
  3. Manuscript Accepted: 27 JUL 2009
  4. Manuscript Revised: 5 JUL 2009
  5. Manuscript Received: 26 FEB 2009

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Keywords:

  • nanoparticles;
  • cytotoxicity;
  • cancer cells;
  • chemotherapeutic agents

Abstract

Functional nanomaterials that included gold, silver nanoparticles and single wall carbon nanotubes were delivered to two cell lines (MLO-Y4 osteocytic cells and HeLa cervical cancer cells) in various concentrations. The cells were found to uptake the nanomaterials in a relatively short time, a process that significantly affected the shape and the size of the cells. The percentage of cellular death, due to the delivery of these nanomaterials, was found to be the highest for carbon nanotubes and increased gradually with the concentration of these nanostructures. Moreover, when the nanomaterials were delivered to the cells combined with commonly used chemotherapeutic agents such as etoposide or dexamethasone, the number of the cells that died increased significantly (100–300%) as compared with the case when only the nanomaterials or the chemotherapeutic agents were delivered. The experimental results were confirmed by Caspase 3 studies, indicating a strong interaction between the nanomaterials used in this study and the protein structure of the cells, which allowed a more effective action of the apoptotic agents. These findings could be the foundation of a new class of cancer therapies that are composed of both chemotherapeutic agents and nanomaterials. Copyright © 2009 John Wiley & Sons, Ltd.

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