Endocrine and testicular changes induced by olanzapine in adult Wistar rats
Article first published online: 21 JUL 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Journal of Applied Toxicology
Volume 33, Issue 1, pages 24–31, January 2013
How to Cite
de Siqueira Bringel, S., de Amorim Júnior, A. A., Amorim, M. J. A. A. L., Brito, L. T., Morais, R. N., de Torres, S. M., Tenorio, B. M. and da Silva Junior, V. A. (2013), Endocrine and testicular changes induced by olanzapine in adult Wistar rats. J. Appl. Toxicol., 33: 24–31. doi: 10.1002/jat.1702
- Issue published online: 29 NOV 2012
- Article first published online: 21 JUL 2011
- Manuscript Accepted: 5 MAY 2011
- Manuscript Revised: 4 MAY 2011
- Manuscript Received: 16 NOV 2010
- sperm production;
- testicular degeneration;
Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment of, and therapeutic support for, schizophrenia, bipolar disorder and other psychoses. Considering that olanzapine acts on the dopaminergic receptor and this receptor is detected in germ cells, the present study aims to investigate the effects of treatment with different doses of olanzapine on spermatogenesis, plasma testosterone and weight of androgen-dependent organs in rats. Results showed reduced plasma testosterone levels, and reduced testis, epididymis and prostate weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Furthermore, germ cell desquamation, syncytial multinucleated cells, Sertoli cell vacuolization and presence of necrotic and apoptotic germ cells wwew observed. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis. Copyright © 2011 John Wiley & Sons, Ltd.