Engineered nanostructural materials for application in cancer biology and medicine
Article first published online: 23 AUG 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Journal of Applied Toxicology
Volume 32, Issue 1, pages 10–19, January 2012
How to Cite
Mahmood, M., Casciano, D., Xu, Y. and Biris, A. S. (2012), Engineered nanostructural materials for application in cancer biology and medicine. J. Appl. Toxicol., 32: 10–19. doi: 10.1002/jat.1718
- Issue published online: 9 DEC 2011
- Article first published online: 23 AUG 2011
- Manuscript Revised: 19 JUN 2011
- Manuscript Accepted: 19 JUN 2011
- Manuscript Received: 23 MAY 2011
- drug delivery;
- gene therapy;
- cancer detection and therapy
Nanotechnology covers a wide variety of fields of research, including chemistry, physics, biology and medicine, with extensive applications in cancer, ranging from accurate, early detection of malignant lesions to minimizing metastasis. Continued development of cancer-targeted therapy has promising advantages: maximizing the effectiveness of anticancer drugs while decreasing the harmful systemic effects; tumor destruction via heating that takes advantage of magnetic nanoparticles' size, magnetization and biocompatibility; novel drug-delivery systems; and gene therapy functions to facilitate controlled drug loading and release inside the cytoplasm. These and other nanotechnology applications can contribute essential new knowledge in the fight against cancer. Copyright © 2011 John Wiley & Sons, Ltd.