Research Article

Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats

  1. Yun Zhang1,
  2. Zhenzhou Jiang1,2,*,
  3. Yijing Su1,
  4. Mi Chen1,
  5. Fu Li1,
  6. Li Liu3,
  7. Lixin Sun1,
  8. Yun Wang1,
  9. Shuang Zhang1,
  10. Luyong Zhang1,4,*

Article first published online: 19 MAR 2012

DOI: 10.1002/jat.2736

Additional Information

How to Cite

Zhang, Y., Jiang, Z., Su, Y., Chen, M., Li, F., Liu, L., Sun, L., Wang, Y., Zhang, S. and Zhang, L. (2012), Gene expression profiling reveals potential key pathways involved in pyrazinamide-mediated hepatotoxicity in Wistar rats. J. Appl. Toxicol.. doi: 10.1002/jat.2736

Author Information

  1. 1

    Jiangsu Center of Drug Screening, China Pharmaceutical University, Nanjing, China

  2. 2

    Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing, China

  3. 3

    The School of Pharmaceutical Engineering and Life Sciences, Changzhou University, Changzhou, China

  4. 4

    JiangSu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, China

*Zhenzhou Jiang, Jiangsu Center of Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. E-mail: jiangcpu@yahoo.com.cn
Luyong Zhang, Jiangsu Center of Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. E-mail: lyzhang@cpu.edu.cn

Publication History

  1. Article first published online: 19 MAR 2012
  2. Manuscript Accepted: 14 JAN 2012
  3. Manuscript Revised: 4 JAN 2012
  4. Manuscript Received: 1 DEC 2011

Funded by

  • Specific Fund for Public Interest Research of Traditional Chinese Medicine, Ministry of Finance. Grant Number: no. 200707008
  • Megaprojects of Science Research for the 11th Five-Year Plan: Standardized Platform Construction and Scientific Application in New Technologies for New Drug. Grant Number: no. 2009ZX09302-002

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