All authors have contributed equally to the review.
Article first published online: 30 MAY 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Journal of Applied Toxicology
Volume 33, Issue 12, pages 1365–1383, December 2013
How to Cite
Bouhifd, M., Hartung, T., Hogberg, H. T., Kleensang, A. and Zhao, L. (2013), Review: Toxicometabolomics. J. Appl. Toxicol., 33: 1365–1383. doi: 10.1002/jat.2874
- Issue published online: 22 OCT 2013
- Article first published online: 30 MAY 2013
- Manuscript Accepted: 11 FEB 2013
- Manuscript Revised: 10 FEB 2013
- Manuscript Received: 5 NOV 2012
- Mapping the Human Toxome by Systems Toxicology. Grant Number: RO1ES020750
- FDA. Grant Number: U01FD004230
- pathways of toxicity;
- toxicity testing for the 21st century;
- analytical chemistry;
- quality assurance
Metabolomics use in toxicology is rapidly increasing, particularly owing to advances in mass spectroscopy, which is widely used in the life sciences for phenotyping disease states. Toxicology has the advantage of having the disease agent, the toxicant, available for experimental induction of metabolomics changes monitored over time and dose. This review summarizes the different technologies employed and gives examples of their use in various areas of toxicology. A prominent use of metabolomics is the identification of signatures of toxicity – patterns of metabolite changes predictive of a hazard manifestation. Increasingly, such signatures indicative of a certain hazard manifestation are identified, suggesting that certain modes of action result in specific derangements of the metabolism. This might enable the deduction of underlying pathways of toxicity, which, in their entirety, form the Human Toxome, a key concept for implementing the vision of Toxicity Testing for the 21st century. This review summarizes the current state of metabolomics technologies and principles, their uses in toxicology and gives a thorough overview on metabolomics bioinformatics, pathway identification and quality assurance. In addition, this review lays out the prospects for further metabolomics application also in a regulatory context. Copyright © 2013 John Wiley & Sons, Ltd.