Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro
Article first published online: 24 OCT 2013
Copyright © 2013 John Wiley & Sons, Ltd.
Journal of Applied Toxicology
Volume 34, Issue 12, pages 1311–1319, December 2014
How to Cite
2014), Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro, J. Appl. Toxicol., 34, pages 1311–1319, doi: 10.1002/jat.2951, , , , and (
- Issue published online: 20 OCT 2014
- Article first published online: 24 OCT 2013
- Manuscript Accepted: 19 SEP 2013
- Manuscript Revised: 14 SEP 2013
- Manuscript Received: 2 AUG 2013
- HK-2 cells;
- Schizandrin B;
Renal proximal tubular epithelial cells are the main targets of toxic drugs such as cisplatin (CisPt), an alkylating agent indicated for the treatment of solid organ tumors. Current techniques aiming at reducing nephrotoxicity in patients receiving CisPt are still not satisfactory as they can only partially prevent acute kidney injury. New nephroprotective strategies remain to be developed. In the present in vitro study, schizandrin (Schi) and schizandrin B (Schi B), major phytochemicals from Schisandra chinensis (Turcz.) Baill. fruits, were tested on HK-2 cells along four processes that could help alleviate CisPt toxicity. Results indicated that: (i) both Schi and Schi B enhanced cell survival via reducing apoptosis rate; (ii) only Schi showed moderate effects towards modulation of regeneration capacities of healthy cells; (iii) both Schi and Schi B limited extracellular matrix deposition; and (iv) both compounds could help preventing dedifferentiation processes via the β-catenin pathway. Schi and Schi B present promising activities for future development of protective agents against CisPt nephrotoxicity. Copyright © 2013 John Wiley & Sons, Ltd.