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Keywords:

  • cisplatin;
  • renal failure;
  • erdosteine

Abstract

The aim of this study was to investigate the optimum dosage of erdosteine to ameliorate cisplatin-induced nephrotoxicity. Three different doses of erdosteine at 25, 50 and 75 mg kg−1 were studied in rats. Intraperitoneal administration of 7 mg kg−1 cisplatin led to acute renal failure, as indicated by kidney histology and increases in plasma creatinine and blood urea nitrogen (BUN) levels. At 5 days after cisplatin injection the BUN level was increased significantly from 15.1 ± 4.3 to 126.7 ± 152.6 mg dl−1 and plasma creatinine levels increased from 0.37 ± 0.005 to 1.68 ± 1.9 mg dl−1. When the rats were administered 50 and 75 mg kg−1 erdosteine 24 h before cisplatin injection that was continued until sacrifice (total of 6 days), the BUN and creatinine levels remained similar to control levels and the grade of histology was similar. Erdosteine at doses of 50 and 75 mg kg−1 ameliorates cisplatin-induced renal failure. The optimum dose of erdosteine may be 50 mg kg−1 in this study. Copyright © 2004 John Wiley & Sons, Ltd.