Dietary fats altered nephrotoxicity profile of methylmercury in rats (pages 126–140)
Xiaolei Jin, Eric Lok, Don Caldwell, Rudi Mueller, Kamla Kapal, Virginia Liston, Stan Kubow, Hing Man Chan and Rekha Mehta
Article first published online: 29 SEP 2008 | DOI: 10.1002/jat.1389
Effects of dietary soy oil, seal oil, docosahexaenoic acid, fish oil and lard on kidney nephrotoxicity of methylmercury were investigated in rats. Regardless of the diets used, MeHg induced numerous significant renal and systemic changes after two weeks of exposure, pointing to a nephrotic syndrome-like renal toxicity. None of the diets used completely eliminated MeHg-induced renal injury; however, they altered the nephrotoxicity profiles of MeHg, suggesting that multiple parameters should be examined to compare MeHg toxicity under different dietary backgrounds.