Benomyl induction of brain aromatase and toxic effects in the zebrafish embryo (pages 289–294)
Dong-Jae Kim, Seung-Hyeok Seok, Min-Won Baek, Hui-Young Lee, Yi-Rang Na, Sung-Hoon Park, Hyun-Kyoung Lee, Noton Kumar Dutta, Koichi Kawakami and Jae-Hak Park
Article first published online: 4 DEC 2008 | DOI: 10.1002/jat.1405
In this study, we determined that benomyl has estrogenic potential based on zebrafish brain aromatase gene induction, and that concentration of 20×10-6 m and higher benomyl induced decreased survival, hatching, heart rates, and increased incidence of malformations, such as pericardial edema, spinal lordosis, elongated heart, head edema, eye lens protrusion, and caudal fin disappearancer in zebrafish embryos. These results demonstrate the usefulness of zebrafish embryos as an in vivo system to examine the estrogenic and developmental toxic potential of unknown compounds.