Increased expression of the testicular estrogen receptor alpha in adult mice exposed to low doses of methiocarb (pages 446–451)
Jiyou Han, Mira Park, Jae-Hong Kim, Ahyoung Kim, Miae Won, Dong Ryul Lee, Jeong-Jae Ko, Ho Yoon, Se-Hoon Sim, Kangseok Lee and Jeehyeon Bae
Version of Record online: 10 FEB 2009 | DOI: 10.1002/jat.1417
Methiocarb is a widely used carbamate pesticide and a suspected endocrine disrupter. The objective of this study was to examine the in vivo effects of methiocarb at low doses on testicular expression of steroid receptors, spermatogenesis, and sperm quality in adult mice. Eighteen-week-old DBA/2 males were treated with daily intraperitoneal injection of methiocarb (0, 0.03, 0.3, 1.0, or 3.0 µg kg−1 of body weight) for 20 days.