Preliminary evaluation of acute toxicity of 188Re–BMEDA–liposome in rats (pages 680–687)
Chi-Mou Liu, Chih-Hsien Chang, Ya-Jen Chang, Chin-Wei Hsu, Liang-Cheng Chen, Hsiao-Lin Chen, Chung-Li Ho, Chia-Yu Yu, Tsui-Jung Chang, Tung-Chuan Chiang and Te-Wei Lee
Version of Record online: 26 OCT 2010 | DOI: 10.1002/jat.1541
Rats receiving the highest activity (185 MBq) of 188Re-BMEDA-liposome showed a significant decrease in WBC count (down to 5–10% of SD 0, P < 0.05) 7 days post injection, but found to recover on SD 15. Some PLT counts in irradiated and control groups were outside the normal range. Throughout the examination period, there were no significant changes in other parameters of hematological analyses in the irradiation or control groups (Table 1). In addition, the levels of liver and kidney enzymes did not alter significantly by 188Re-BMEDA-liposome treatment throughout the observation period (Table 2). Furthermore, the frequencies of DCs were associated with dosage of 188Re-BMEDA-liposome (Table 3).