Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation (pages 761–768)
Marcos Raniel Straliotto, Gianni Mancini, Jade de Oliveira, Evelise Maria Nazari, Yara Maria Rauh Müller, Alcir Dafre, Susana Ortiz, Edson Luiz Silva, Marcelo Farina, Alexandra Latini, João Batista Teixeira Rocha and Andreza Fabro de Bem
Article first published online: 13 JUL 2010 | DOI: 10.1002/jat.1560
In this study, we evaluated the effects of acute intraperitoneally administration of (PhSe)2 (5–500 µmol.kg−1) on toxicological parameters in rabbits. Exposure to the highest dose caused 85% mortality, while, the treatment with 5 and 50 µmol.kg−1 of (PhSe)2 improved the redox system in different tissues. Hepatic and renal biochemical and histological parameters were not modified by (PhSe)2. These results indicated that acute toxicology to (PhSe)2 in rabbit is dependent with the dose, which should motivate further experiments on the therapeutic properties of this compound.