Finding maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in rat testis (pages 421–430)
Xiaolian Yuan, Martijs J. Jonker, Jillian de Wilde, Aart Verhoef, Floyd R.A. Wittink, Jan van Benthem, Jos G. Bessems, Betty C. Hakkert, Raoul V. Kuiper, Harry van Steeg, Timo M. Breit and Mirjam Luijten
Article first published online: 9 NOV 2010 | DOI: 10.1002/jat.1601
In vivo toxicity testing can potentially be improved by the introduction of microarray technology. We investigated the potential of applying toxicogenomics in reprotoxicity testing in an exposure study with reprotoxic and non-reprotoxic phthalates. Tissue from testis from treated male rats was used for concurrent histopathological and transcriptome analyses. We identified the maximal transcriptome differences between reprotoxic and non-reprotoxic phthalate responses in our study and showed that a transcriptomics approach may lead to predictive biomarkers for reprotoxic phthalates.