The extract of the jellyfish Phyllorhiza punctata promotes neurotoxic effects (pages 720–729)
Raquel Felipe Vasconcelos Carneiro, Nilberto Robson Falcão do Nascimento, Paula Priscila Correia Costa, Victor Martins Gomes, Alex Jardelino Felizardo de Souza, Simone Cristina Buzzo de Oliveira, Eduardo Britto dos Santos Diz Filho, Fernando José Zara, Manassés Claudino Fonteles, Daniela de Oliveira Toyama, Marcos Hikari Toyama and Cláudia Ferreira Santos
Version of Record online: 11 FEB 2011 | DOI: 10.1002/jat.1620
Herewith we present the biochemical and pharmacological characterization of an extract of the tentacles of the jellyfish P. punctata (PHY-N). Paralytic shellfish poisoning (PSP) compounds as well as secretory phospholipase A2 (sPLA2) were identified. The extract induced phasic contractions in the mouse vas deferens, sustained relaxation of the mouse corpora cavernosa and a sustained tonic contraction of the biventer-cervicis neuromuscular preparation. Administration of PHY-N provoked death of broilers by spastic paralysis. PHY-N induces nerve depolarization and nonspecifically increases neurotransmitter release.