Time-dependent biodistribution and excretion of silver nanoparticles in male Wistar rats (pages 920–928)
K. Dziendzikowska, J. Gromadzka-Ostrowska, A. Lankoff, M. Oczkowski, A. Krawczyńska, J. Chwastowska, M. Sadowska-Bratek, E. Chajduk, M. Wojewódzka, M. Dušinská and M. Kruszewski
Version of Record online: 13 JUN 2012 | DOI: 10.1002/jat.2758
In the present study, the effect of 20 and 200 nm silver nanoparticles (AgNPs) on their intracellular uptake, tissue distribution and excretion at different time points was evaluated. AgNPs were found in various tissues and a concentration of 20 nm AgNPs was higher compared with 200 nm. Preferential distribution was observed in the liver after 24 h and in the lungs 7 days after the AgNPs exposure. Twenty-eight days after the injection, the highest Ag content was found in the kidneys and brain.