Aluminium chloride promotes anchorage-independent growth in human mammary epithelial cells (pages 233–243)
André-Pascal Sappino, Raphaële Buser, Laurence Lesne, Stefania Gimelli, Frédérique Béna, Dominique Belin and Stefano J. Mandriota
Version of Record online: 6 JAN 2012 | DOI: 10.1002/jat.1793
Aluminum salts in antiperspirants have been incriminated as contributing to breast cancer incidence in western societies. To date, no epidemiological or experimental data confirm or infirm this hypothesis. In human mammary epithelial cells, chronic exposure to aluminum concentrations up to 100'000 fold lower than those found in antiperspirants results in loss of contact inhibition and growth in soft agar. Our observations do not formally identify aluminum as a breast carcinogen, but challenge the safety ascribed to its wide use in underarm cosmetics.