In vitro toxicity of aflatoxin B1 and its photodegradation products in HepG2 cells (pages 276–281)
Ruijie Liu, Qingzhe Jin, Jianhua Huang, Yuanfa Liu, Xingguo Wang, Xinglong Zhou, Wenyue Mao and Shanshan Wang
Version of Record online: 18 MAR 2011 | DOI: 10.1002/jat.1669
Cytotoxicity, apoptosis and p53 expression were assessed after exposure to different concentrations of AFB1 (0–100 μm) and its two types of degradation products, namely the mixtures of photodegradation products in water (Pw) and the mixtures of photodegradation products in peanut oil (Po) for different time periods (0, 24, and 48 h). The results of the in vitro cytotoxicity assay indicate that Pw is less toxic than AFB1, and Po has almost no toxicity, which can be explained by the differences in the chemical nature of the various kinds of the test compounds.