Raman spectroscopy as a detection and analysis tool for in vitro specific targeting of pancreatic cancer cells by EGF-conjugated, single-walled carbon nanotubes (pages 365–375)
Alokita Karmakar, Cornel Iancu, Dana Monica Bartos, Meena W. Mahmood, Anindya Ghosh, Yang Xu, Enkeleda Dervishi, Samuel L. Collom, Mariya Khodakovskaya, Thikra Mustafa, Fumiya Watanabe, Alexandru R. Biris, Yongbin Zhang, Syed F. Ali, Dan Casciano, Samar Hassen, Zeid Nima and Alexandru S. Biris
Article first published online: 6 DEC 2011 | DOI: 10.1002/jat.1742
Single walled carbon nanotubes (SWNTs) covalently linked to EGF proteins can be specifically delivered to human pancreatic cancer cells and are internalized by the cells at a greater level than exposure of the cells to simple SWCNTs. Raman spectroscopy proved to be a powerful technique to monitor the interactions between nanotubes both conjugated and unconjugated with EGF and the cells.