Chlorpyrifos exposure reduces reproductive capacity owing to a damaging effect on gametogenesis in the nematode Caenorhabditis elegans (pages 527–535)
Qin-Li Ruan, Jing-Juan Ju, Yun-Hui Li, Xiao-Bo Li, Ran Liu, Ge-Yu Liang, Juan Zhang, Yue-Pu Pu, Da-Yong Wang and Li-Hong Yin
Article first published online: 19 DEC 2011 | DOI: 10.1002/jat.1783
The present study aims to investigate reproductive toxicity of chlorpyrifos exposure and the possible mechanism using the nematode Caenorhabditis elegans. Accompanied by decreased brood size, the morphology of sperm and oocyte were altered and sperm motility and oocyte quality were reduced. Moreover, genes involved in spermatogenesis and oogenesis were altered to some degree. Therefore, chlorpyrifos exposure may lead to adverse effects on the fertility of nematodes by influencing both the spermatogenesis and the oogenesis.