Endocrine and testicular changes induced by olanzapine in adult Wistar rats (pages 24–31)
Simone de Siqueira Bringel, Adelmar Afonso de Amorim Júnior, Marleyne José Afonso Accioly Lins Amorim, Lorena Tavares Brito, Rosana Nogueira Morais, Sandra Maria de Torres, Bruno Mendes Tenorio and Valdemiro Amaro da Silva Junior
Article first published online: 21 JUL 2011 | DOI: 10.1002/jat.1702
Olanzapine is an atypical antipsychotic drug that has been increasingly used in acute treatment and therapeutic support for schizophrenia. Olanzapine treatment induced a reduction in plasma testosterone levels, and testicular, epididymal and prostatic weights. Histopathologic and histomorphometric analysis of spermatogenesis indicated testicular degeneration. Olanzapine treatment in rats promoted endocrinological changes and lesions in the testis, leading to a disturbance in spermatogenesis.