Rat pancreatitis produced by 13-week administration of zinc oxide nanoparticles: biopersistence of nanoparticles and possible solutions (pages 1089–1096)
Seung Hyeok Seok, Wan-Seob Cho, Jung Shin Park, Yirang Na, Ahram Jang, Hojoong Kim, Yujin Cho, Taesung Kim, Ji-Ran You, Sanghoon Ko, Byeong-Cheol Kang, Jong Kwon Lee, Jayoung Jeong and Jeong-Hwan Che
Version of Record online: 13 FEB 2013 | DOI: 10.1002/jat.2862
Zinc oxide (ZnO) nanoparticles (NPs) have been used for diverse applications including paints, cosmetics, biomedicine, and food. ZnO NPs can cause pancreatitis and anemia and this might be an important data for toxicity and risk assessment of ZnO NP in subchronic 13-week toxicity study vial oral route in rats. The bio-persistence of ZnO NPs after ingestion is key to their toxicity; the no-observed-adverse effect level (NOAEL) of ZnO NPs was found to be 268.4mgkg–1 per day for both sexes.