Maternal lead exposure during lactation persistently impairs testicular development and steroidogenesis in male offspring (pages 1384–1394)
Hua Wang, Yan-Li Ji, Qun Wang, Xian-Feng Zhao, Huan Ning, Ping Liu, Cheng Zhang, Tao Yu, Ying Zhang, Xiu-Hong Meng and De-Xiang Xu
Version of Record online: 13 JUL 2012 | DOI: 10.1002/jat.2795
Lead (Pb) is a testicular toxicant. In the present study, we investigated the effects of maternal Pb exposure during lactation on testicular development and steroidogenesis in male offspring. Maternal mice were exposed to different concentration of lead acetate (200 or 2000 ppm) through drinking water from postnatal day (PND) 0 to PND21. Results showed that Pb could be transported from dams to pups through milk. Maternal Pb exposure during lactation persistently disrupted testicular development and steroidogenesis in male offspring.