ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension (pages 227–237)
Justin N. Weilnau, Sarah E. Black, Veronica J. Chehata, Michael P. Schmidt, Kimberly L. Holt, Lindsay M. Carl, Collin J. Straka, Anderson L. Marsh, Walter A. Patton and Courtney M. Lappas
Article first published online: 14 SEP 2012 | DOI: 10.1002/jat.2811
Nanocrystals are potentially useful for a variety of biological applications. We have synthesized zinc sulfide (ZnS) semiconductor nanocrystals in the 3- to 4-nm size range with selected capping agents intended to protect the nanocrystal core and increase its biological compatibility. We show that the biocompatibility of ZnS nanocrystals with primary murine splenocytes is influenced by both the chemical structure of the outer capping agent on the nanocrystal as well as the duration of time the nanocrystal is stored in suspension.