Molecular insights into the progression of crystalline silica-induced pulmonary toxicity in rats (pages 301–312)
Rajendran Sellamuthu, Christina Umbright, Jenny R. Roberts, Amy Cumpston, Walter McKinney, Bean T. Chen, David Frazer, Shengqiao Li, Michael Kashon and Pius Joseph
Article first published online: 19 MAR 2012 | DOI: 10.1002/jat.2733
Rats were exposed to crystalline silica and global gene expression profile was determined in the lungs at post-exposure time intervals. The number of significantly differentially expressed genesin the rat lungs correlated with silica-induced pulmonary toxicity. Genes involved in oxidative stress, inflammation, respiratory diseases, cancer, and tissue remodeling and fibrosis were significantly differentially expressed in the lungs. Collectively, the findings of our study provided insights into the molecular mechanisms underlying the progression of crystalline silica-induced pulmonary toxicity in the rat.