Toxicokinetic study of melamine in the presence and absence of cyanuric acid in rats (pages 444–450)
Jing Pang, Guo-Qing Li, Cong-Ran Li, Xin-Yi Yang, Xi Lu, Xin-Xin Hu, Qian-Qian Zhai, Wei-Xin Zhang, Jian-Dong Jiang and Xue-Fu You
Article first published online: 17 NOV 2011 | DOI: 10.1002/jat.1764
A toxicokinetic study was conducted to compare the toxicokinetics of melamine (MEL) in the presence and absence of cyanuric acid (CYA), and to elucidate the correlation between toxicity and kinetic properties of MEL. CYA co-administration could lower absorption, slower excretion and induce tissue accumulation of MEL, which correlated well with the generation and development of renal toxicity. In conclusion, co-administration with CYA leads to the alteration of the kinetic characteristics of MEL, which provides an additional explanation to renal toxicity.