Chronic exposure to low concentrations of strontium 90 affects bone physiology but not the hematopoietic system in mice (pages 76–86)
Nicholas Synhaeve, Ndéye Marième Wade-Gueye, Stefania Musilli, Johanna Stefani, Line Grandcolas, Gaëtan Gruel, Maâmar Souidi, Isabelle Dublineau and Jean-Marc Bertho
Version of Record online: 16 NOV 2012 | DOI: 10.1002/jat.2834
The effect of chronic ingestion of strontium 90 was investigated in a mouse model, with strontium 90 concentrations representative of environmental contamination after a major nuclear accident. Results did not show evidence for modifications in the hematopoietic system. By contrast, a modification of bone metabolism was demonstrated, but was not linked to phosphocalcic homeostasis. This suggests a direct effect of strontium 90 storage in the bones on osteoblasts and/or osteoclasts.