Identification of metabolomic biomarkers for drug-induced acute kidney injury in rats (pages 1087–1095)
Takeki Uehara, Akira Horinouchi, Yuji Morikawa, Yutaka Tonomura, Keiichi Minami, Atsushi Ono, Jyoji Yamate, Hiroshi Yamada, Yasuo Ohno and Tetsuro Urushidani
Article first published online: 30 SEP 2013 | DOI: 10.1002/jat.2933
Metabolomics involves the comprehensive and simultaneous determination of endogenous or exogenous metabolites in biological samples. The present study aimed to identify metabolomic biomarkers that could provide early and sensitive indication of nephrotoxicity in rats. Metabolomic analyses were performed using CE-TOFMS on rat plasma treated with several nephrotoxicants. Among a total of 169 metabolites identified, 3-methylhistidine, 3-indoxyl sulfate, and guanidoacetate were selected as candidate biomarkers, which may prove to be valuable plasma biomarkers for monitoring nephrotoxicity in rats.