Molecular impact of juvenile hormone agonists on neonatal Daphnia magna (pages 537–544)
Kenji Toyota, Yasuhiko Kato, Hitoshi Miyakawa, Ryohei Yatsu, Takeshi Mizutani, Yukiko Ogino, Shinichi Miyagawa, Hajime Watanabe, Hiroyo Nishide, Ikuo Uchiyama, Norihisa Tatarazako and Taisen Iguchi
Article first published online: 5 SEP 2013 | DOI: 10.1002/jat.2922
DNA microarray was used to evaluate gene expression profiles of neonatal Daphnia magna exposed to juvenile hormone (JH) agonists; methoprene, fenoxycarb and epofenonane. JH analogs induced chemical specific patterns of gene expression. Hemoglobin and JH epoxide hydrolase genes were clustered to be JH-responsive genes. Fenoxycarb has high activity as a JH agonist, methoprene shows high toxicity and epofenonane works through a different mechanism. D. magna DNA microarray is useful for classification of JH analogs and identification of JH-responsive genes.