Characterization of the components of urban particulate matter mediating impairment of nitric oxide-dependent relaxation in intrapulmonary arteries (pages 667–674)
Arnaud Courtois, Caroline Prouillac, Isabelle Baudrimont, Céline Ohayon-Courtes, Véronique Freund-Michel, Mathilde Dubois, Mariette Lisbonne-Autissier, Roger Marthan, Jean-Pierre Savineau and Bernard Muller
Article first published online: 23 JUL 2013 | DOI: 10.1002/jat.2909
We have previously shown that exposure to urban particulate matter (UPM) impairs endothelial nitric oxide (NO) bioactivity in intrapulmonary arteries. Since UPM is composed of heterogeneous constituents, the present study was designed to clarify the class of pollutants being responsible for such effect. We showed that UPM-induced impairment of endothelial NO bioactivity unlikely involved a soluble factor released by vascular cells, but organic extractible and acidic-sensitive constituents of UPM. Among those constituents, endotoxin may be responsible for such impairment.