Biological effect of food additive titanium dioxide nanoparticles on intestine: an in vitro study (pages 1169–1178)
Zheng-Mei Song, Ni Chen, Jia-Hui Liu, Huan Tang, Xiaoyong Deng, Wen-Song Xi, Kai Han, Aoneng Cao, Yuanfang Liu and Haifang Wang
Article first published online: 23 JUN 2015 | DOI: 10.1002/jat.3171
Titanium dioxide nanoparticles (TiO2 NPs) are widely used in food products; therefore, understanding their effect and absorption on the intestinal barrier is vital. Bioeffects of two native and digestion fluids or bovine serum albumin pretreated TiO2 NPs were studied on the Caco-2 cells and monolayer. The results indicate that all TiO2 NPs were non-toxic to the differentiated Caco-2 cells and monolayer, differentiation of cells and protein coating impeded the cellular uptake of NPs, and it was difficult for NPs to traverse through the Caco-2 monolayer.