Long-term retention of pristine multi-walled carbon nanotubes in rat lungs after intratracheal instillation (pages 501–509)
Naohide Shinohara, Tetsuya Nakazato, Kumiko Ohkawa, Moritaka Tamura, Norihiro Kobayashi, Yasuo Morimoto, Takako Oyabu, Toshihiko Myojo, Manabu Shimada, Kazuhiro Yamamoto, Hiroaki Tao, Makoto Ema, Masato Naya and Junko Nakanishi
Article first published online: 29 DEC 2015 | DOI: 10.1002/jat.3271
Well-dispersed pristine MWCNTs were administered to rats at doses of 0.20 or 0.55 mg via intratracheal instillation, and investigated clearance over a 12-month observation period. Approximately 30% of administrated MWCNTs may have been cleared by bronchial ciliary motion within 24 h of administration. After that, the pulmonary MWCNT burden did not decrease significantly over time for up to 364 days after instillation, suggesting that MWCNTs were not readily cleared from the lung. MWCNTs were not detected in the liver or brain within the 364-day study period.